Dolutegravir, Lamivudine, Tenofovir Disoproxil Fumarate tablets 50 mg/300 mg/300 mg – XAPAVIR LT Tablet

Xapavir-LT is a combination antiretroviral medication containing Dolutegravir (50 mg), Lamivudine (300 mg), and Tenofovir Disoproxil Fumarate (TDF) (300 mg). This powerful trio is designed to help manage and treat HIV-1 infection in adults and certain pediatric patients. By targeting multiple stages of the HIV lifecycle, Xapavir-LT effectively reduces the viral load, helping to preserve and improve immune function.

How Xapavir-LT Works

Xapavir-LT combines three active ingredients that work synergistically to combat HIV:

• Dolutegravir (50 mg): An integrase strand transfer inhibitor (INSTI) that blocks the HIV integrase enzyme, preventing the virus from integrating its genetic material into the host cell’s DNA. This inhibits the replication of the virus within the body.
• Lamivudine (300 mg): A nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the reverse transcriptase enzyme, which HIV uses to convert its RNA into DNA. By disrupting this process, Lamivudine helps to reduce the amount of HIV in the blood.
• Tenofovir Disoproxil Fumarate (TDF) (300 mg): Another NRTI that inhibits the reverse transcriptase enzyme, further decreasing HIV replication and viral load.

Indications and Usage

Xapavir-LT is prescribed for the treatment of:

• HIV-1 Infection: In combination with other antiretroviral agents for patients who have not previously received treatment for HIV-1 infection.
• Maintenance Therapy: For patients who have achieved viral suppression with a stable antiretroviral regimen.

Note: Xapavir-LT is not a cure for HIV/AIDS. It is part of a comprehensive treatment plan that includes regular medical monitoring and adherence to prescribed therapies.

Dosage and Administration

• Recommended Dose: Take one tablet of Xapavir-LT once daily, with or without food.
• Administration Tips:
  • Swallow the tablet whole with a glass of water.
  • Maintain a consistent dosing schedule to maximize effectiveness.
  • Do not alter the dose or discontinue use without consulting your healthcare provider.

Possible Side Effects

Like all medications, Xapavir-LT may cause side effects. Common side effects include:

• Nausea
• Headache
• Diarrhea
• Fatigue
• Insomnia

Serious Side Effects (seek medical attention immediately if you experience):

• Severe Allergic Reactions: Rash, itching, swelling, severe dizziness, trouble breathing.
• Liver Problems: Yellowing of the skin or eyes, dark urine, persistent nausea or vomiting.
• Bone Density Loss: Increased risk of fractures or osteoporosis.
• Kidney Problems: Changes in urine output, swelling in extremities.

Precautions and Warnings

Before taking Xapavir-LT, inform your healthcare provider if you:

• Have a history of liver or kidney disease.
• Are pregnant, planning to become pregnant, or breastfeeding.
• Are taking other medications, including over-the-counter drugs and supplements, to avoid potential interactions.
• Have a history of lactic acidosis or severe liver problems.
• Have osteoporosis or are at risk for bone density loss.

Important: Do not take Xapavir-LT if you are allergic to Dolutegravir, Lamivudine, Tenofovir Disoproxil Fumarate, or any other component of the medication.

Drug Interactions

Xapavir-LT may interact with other medications, which can affect how Xapavir-LT or the other drugs work. Inform your healthcare provider about all the medications you are taking, including:

• Antacids and Supplements: Can affect the absorption of Dolutegravir.
• Certain Antibiotics and Antifungals: May require dosage adjustments.
• Other Antiretrovirals: Potential for increased side effects or reduced efficacy.
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Increased risk of kidney problems.

Storage Instructions

• Keep Xapavir-LT in its original packaging, tightly closed.
• Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Protect from Moisture and Heat: Do not store in the bathroom or other humid areas.
• Keep Out of Reach of Children.