Dolutegravir and Lamivudine Tablets [50 mg + 300 mg] – Twinaqt

Twinaqt is a combination antiretroviral medication containing Dolutegravir (50 mg) and Lamivudine (300 mg). This powerful combination is designed to help manage and treat HIV-1 infection in adults and certain pediatric patients. By targeting multiple stages of the HIV lifecycle, Twinaqt effectively reduces the viral load, helping to preserve and improve immune function.

How Twinaqt Works

Twinaqt combines two active ingredients that work synergistically to combat HIV:

• Dolutegravir: An integrase strand transfer inhibitor (INSTI) that blocks the HIV integrase enzyme, preventing the virus from integrating its genetic material into the host cell’s DNA. This inhibits the replication of the virus within the body.
• Lamivudine: A nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the reverse transcriptase enzyme, which HIV uses to convert its RNA into DNA. By disrupting this process, Lamivudine helps to reduce the amount of HIV in the blood.

Indications and Usage

Twinaqt is prescribed for the treatment of:

• HIV-1 Infection: In combination with other antiretroviral agents for patients who have not previously received treatment for HIV-1 infection.
• Maintenance Therapy: For patients who have achieved viral suppression with a stable antiretroviral regimen.

Note: Twinaqt is not a cure for HIV/AIDS. It is part of a comprehensive treatment plan that includes regular medical monitoring and adherence to prescribed therapies.

Dosage and Administration

• Recommended Dose: Take one tablet of Twinaqt once daily, with or without food.
• Administration Tips:
  • Swallow the tablet whole with a glass of water.
  • Maintain a consistent dosing schedule to maximize effectiveness.
  • Do not alter the dose or discontinue use without consulting your healthcare provider.

Possible Side Effects

Like all medications, Twinaqt may cause side effects. Common side effects include:

• Nausea
• Headache
• Diarrhea
• Fatigue
• Insomnia

Serious Side Effects (seek medical attention immediately if you experience):

• Severe Allergic Reactions: Rash, itching, swelling, severe dizziness, trouble breathing.
• Liver Problems: Yellowing of the skin or eyes, dark urine, persistent nausea or vomiting.
• Mood Changes: Depression, anxiety, or unusual mood swings.

Precautions and Warnings

Before taking Twinaqt, inform your healthcare provider if you:

• Have a history of liver or kidney disease.
• Are pregnant, planning to become pregnant, or breastfeeding.
• Are taking other medications, including over-the-counter drugs and supplements, to avoid potential interactions.
• Have a history of lactic acidosis or severe liver problems.

Important: Do not take Twinaqt if you are allergic to Dolutegravir, Lamivudine, or any other component of the medication.

Drug Interactions

Twinaqt may interact with other medications, which can affect how Twinaqt or the other drugs work. Inform your healthcare provider about all the medications you are taking, including:

• Antacids and Supplements: Can affect the absorption of Dolutegravir.
• Certain Antibiotics and Antifungals: May require dosage adjustments.
• Other Antiretrovirals: Potential for increased side effects or reduced efficacy.

Storage Instructions

• Keep Twinaqt in its original packaging, tightly closed.
• Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Protect from Moisture and Heat: Do not store in the bathroom or other humid areas.
• Keep Out of Reach of Children.